Assistant Professor, Chemical & Biomolecular Engineering,
Dr. Nagrath's research interests lie in the application of nutritional systems-biology approaches in highly challenging, cutting edge problems in clinical disciplines such as metabolic syndrome, liver fibrosis, and regenerative medicine. Nutritional systems biology (NSB) is defined as the approach to understand the key processes that regulate metabolism at all levels of complexity and to predict the outcome of any alteration of the system by utilizing metabolic tools. He uses transcriptional and metabolic design principles to analyze healthy and diseased biological states. His research focuses on various diseases such as metabolic syndrome, cancer, and diabetes, and potential treatments using metabolic supplementation and embryonic stem cells. Dr. Nagrath makes a concerted effort to use engineering principles, such as multiobjective optimality and nonequilibrium thermodynamics, for analyzing complex disease states. His research integrates both experimental and theoretical tools to develop a recipe for maintaining normal function of various organs. The goal of his work is to offer an important window to understand the role of environmental stress/factors interactions with the cellular components, and in modulating those interactions optimally to improve human health. In an effort towards understanding the energetic basis of embryonic stem cells (ESC) transcriptional network, Professor Nagrath is focusing on developing framework that can predict the abundance of topological motifs in the transcriptional regulatory network using combined thermodynamics and Pareto optimality analysis.
Deepak Nagrath joins Rice as an assistant professor in the department of Chemical and Biomolecular Engineering after serving as a research associate in the Department of Surgery at Massachusetts General Hospital and Harvard Medical School.
Nagrath’s research interests lie in the application of systems-biology approaches to human diseases. He uses transcriptional and metabolic design principles to analyze healthy and diseased biological states. His research focuses on various diseases such as metabolic syndrome, cancer, and diabetes, and potential treatments using metabolic supplementation and embryonic stem cells. Nagrath uses engineering principles such as multi-objective optimality and non-equilibrium thermodynamics for analyzing complex disease states.
Nagrath, who is from India, earned a doctorate in chemical engineering and a master’s degree in applied mathematics from Rensselaer Polytechnic Institute in Troy, New York in 2003. He received a bachelor’s degree in chemical engineering from the Indian Institute of Technology in Roorke, India.